Expired Study
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Nashville, Tennessee 37212


Purpose:

Collect exhaled breath condensates from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of IsoFs Draw blood from patients scheduled for a routine surgical procedure before, during, and after surgery for measurements of serum thrombomodulin.


Study summary:

High concentrations of oxygen are routinely administered to patients undergoing routine surgical procedures even though it is highly likely, at least in patients with normal lung function, that this is unnecessary and in fact may be doing unnecessary harm. Therefore, we plan to assess whether there is any evidence of lung injury during surgery resulted from administration of high concentrations of oxygen by measuring Isofurans (IsoFs) in exhaled breath condensate. In our studies in mice that were exposed to high concentrations of oxygen we also found that circulating levels of thrombomodulin were increased. Thrombomodulin is present in endothelial cells and upon injury they release thrombomodulin into the circulation. Endothelial cell injury is known to occur in hyperoxic-induced lung injury. Therefore, in addition to measuring IsoFs in exhaled breath condensate we will also measure plasma concentrations of thrombomodulin as an indicator of endothelial injury.


Criteria:

Inclusion Criteria: - American Society of Anesthesiologists (ASA) Class I-III. - Patient is undergoing elective surgery requiring mechanical ventilation - Patient is an adult, 18 - 80 years old. - Subject has voluntarily signed and dated the informed consent document approved by the Institutional Review Board (IRB). Exclusion Criteria: - Surgical procedures boarded for less than 2 hours - Current Smoker - All Cardiac, Thoracic and/or Vascular surgeries involving the chest - Patient unable to cooperate. - Chronic airway diseases - Asthma - Medical contraindication to anesthetic technique (allergy, cardiac condition, neurologic condition, localized infection, bleeding disorder). - Subjects who are pregnant.


NCT ID:

NCT00715338


Primary Contact:

Principal Investigator
John A Barwise, M.D.
Vanderbilt University Medical Center


Backup Contact:

N/A


Location Contact:

Nashville, Tennessee 37212
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2018

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