King of Prussia,
Subjects will receive their first dose of darapladib in the clinical research unit (CRU),
and the remaining 9 days of dosing will occur at home. Subjects will record any adverse
events throughout the dosing period in a paper diary. Subjects will return to the CRU 10-14
days after the last dose of darapladib for a follow-up visit. The total study duration for
each subject including the screening, treatment and follow-up periods will be approximately
- Healthy as determined by a responsible physician, based on a medical evaluation
including medical history, physical examination, laboratory tests and ECG.
- Male or female between 18 and 65 years of age inclusive, at the time of signing the
- A female subject is eligible to participate if she is of:
- Non-childbearing potential defined as pre-menopausal females with a documented
tubal ligation or hysterectomy; or postmenopausal defined as 12 months of
- Child-bearing potential and agrees to use one of the contraception methods
listed in the protocol for an appropriate period of time (as determined by the
product label or investigator) prior to the start of dosing to sufficiently
minimize the risk of pregnancy at that point. Female subjects must agree to use
contraception until the follow-up visit.
- Body weight >= 50 kg and BMI within the range 19 - 30 kg/m2 (inclusive).
- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.
- QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch Block.
- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.
- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).
- Exposure to more than four new chemical entities within 12 months prior to the first
- History of drug abuse.
- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.
- History of anaphylaxis, anaphylactoid reactions and severe allergic responses.
- History of adult asthma manifested by bronchospasms in the past 6 months or currently
taking regular anti-asthmatic medication.
- Currently receiving oral or injectable strong CYP3A4 inhibitor(s).
- Consumption of grapefruit or grapefruit juice within 7 days prior to first dose of
- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.
- Pregnant females as determined by positive serum hCG test at screening.
- Lactating females.
- Unwillingness or inability to follow the procedures outlined in the protocol.