Expired Study
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Columbus, Ohio 43210


Purpose:

The purpose of this study is to see if taking a cholesterol lowering drug (LIPITOR®) will increase the number of endothelial progenitor cells (EPC's) circulating in the blood of heart failure patients taking this cholesterol-lowering drug, and if this will also show an improvement in the damaged areas of the patient's hearts as documented by MRI scans.


Study summary:

This study involves the testing of blood for cholesterol levels and flow cytometry tests to count the number of EPC's in your blood. These tests are routinely performed to gain knowledge about a person's health. If any incidental findings are identified as a result of your participation in this research study, you will be notified and referred to your doctor or appropriate health care professional. You are being asked to provide a blood sample that will be used to determine the usual numbers of EPC's circulating in the blood of healthy people who have no risk factors for heart disease. Your results will be compared with those of patients who have heart failure. Flow cytometry is a special laboratory test that can count, separate, and detect characteristics of cells in blood. Your blood sample will be analyzed using flow cytometry. Endothelial progenitor cells (EPC's) are immature cells that are necessary for new blood vessel formation. EPC's will be separated by flow cytometry and counted. You will not be given the results of your flow cytometry study.


Criteria:

Inclusion Criteria: - Ischemic Cardiomyopathy (as defined above) with ejection fraction < 35% - Non-ischemic Cardiomyopathy with ejection fraction < 35% - NCEP ATPIII indication for therapy with a statin drug - No statin therapy within previous 6 months of study enrollment - Prescribed stable doses of standard heart failure therapies including beta blocking agents, angiotensin converting enzyme inhibitors or angiotensin receptor blockers, and diuretic agents as required Exclusion Criteria: - Pregnant or lactating - Myocardial infarction within 6 months preceding study enrollment - Primary valvular heart disease - Surgical or catheter based revascularization within the preceding 6 months - Documented viral or inflammatory myocarditis or cardiomyopathy - Peripartum cardiomyopathy - Infiltrative cardiomyopathies - Chemotherapy associated cardiomyopathy - Without indication for statin therapy - Contraindication to statin therapy including hepatic dysfunction, history of rhabdomyolysis or prior intolerance of statin therapy - Contraindication to magnetic resonance imaging


NCT ID:

NCT00701220


Primary Contact:

Principal Investigator
Philip Binkley, MD, MPH
Ohio State University


Backup Contact:

N/A


Location Contact:

Columbus, Ohio 43210
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 19, 2018

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