The purpose of this study is to evaluate the effects of a combination of hydroxcycitrate
(HCA) and niacin-bound chromium, in conjunction with nutrition education, over a twelve week
period. Participants will be evaluated with regard to BMI, percent body fat, insulin
activity, and hunger.
The prevalence of obesity among youth has increased dramatically in recent years. Parallel
to the increased rates of pediatric obesity, overweight children present clinically with
adiposity related comorbidities such as insulin resistance and type 2 diabetes. The
prevailing recommendations for overweight youth are to increase physical activity levels and
limit energy intake in order to improve body composition. Currently there is little
empirical evidence to support the efficacy of these recommendations. Alternatively, evidence
in adults suggests that nutritional supplementation with (-) hydroxycitric acid (HCA), an
organic acid found naturally in citrus fruits, and chromium may lead to favorable changes in
body composition and improve glucose regulation. To date, these issues have not been tested
in youth. Therefore, the purpose of the present investigation is to examine the effects of a
nutritional education program combined with either HCA + chromium or placebo on measures of
body composition and glucose regulation in overweight adolescents.
- All subjects will be between 13 and 17 years of age
- All subjects will be overweight as defined by an age & sex-specific body mass
index ≥ 85th percentile based on CDC BMI growth charts [US Department of Health
and Human Services, 2000], calculated by Epi Info Software, version 3.3.
- Presently taking any prescribed medication(s) or diagnosed with any syndrome or
disease that could influence dietary intake, body composition and fat distribution,
or insulin action or secretion.
- Previously diagnosed with any major illness since birth (e.g. sever intrauterine
growth retardation, chronic birth asphyxia, cancer).
- Children with type 1 and/or type 2 diabetes will be excluded are referred to a
- Currently involved with any dietary, exercise, or weight loss program or have been in
the 6 months prior to participation.
- Unexplained weight loss or gain in the prior six months.
- Oral contraception use in sexually active females
- Children who live further than 20 miles away from the USC Health Science Campus