This is an observational study examining serum markers in patients who are undergoing either
a cadaveric liver transplant or a living related liver transplant.
The Departments of Anesthesiology are conducting an observational trial of markers in the
serum of patients who are undergoing liver transplantation surgery. This study will utilize
the biological markers, trimethylamine-N-oxide (TMAO), NGAL, and cystatin-C, sensitive
markers of renal medullary injury in the blood and allantoin, a marker of oxidative stress
as indicators of renal injury in a kidney during liver transplants. It is hypothesized that:
(1) these markers are less pronounced in living donor liver transplant recipient patients
than in cadaveric liver transplant recipients, and (2) these markers are less pronounced in
cadaveric liver transplant recipients in which a "piggy-back" technique was used versus
recipients in which a total venous occlusion technique was used. This study will be done in
a multi-center format, along with researchers at UCSF
- American Society of Anesthesiologists (ASA) Class I-V.
- Patient is undergoing elective Liver Transplant Surgery.
- Patient is an adult, 18 years old or older.
- Patients < 18 Years of Age
- Patients who are pregnant