Expired Study
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Rochester, Minnesota 55901


Purpose:

Compare the percent of subjects with moderate/severe esophagitis who achieve complete endoscopic resolution after 8 weeks of treatment morning vs. bedtime.


Study summary:

Hypothesis: The timing of administration of omeprazole/sodium bicarbonate (Zegerid) will impact nocturnal esophageal acid exposure and healing of esophagitis. Specifically, we hypothesize that omeprazole/sodium bicarbonate, taken at bedtime, will be superior in healing esophagitis compared to omeprazole/sodium bicarbonate taken in the morning. Specific Aim: Compare the percent of subjects with moderate/severe esophagitis who achieve complete endoscopic resolution after 8 weeks of treatment (morning vs. bedtime).


Criteria:

Inclusion Criteria: - Age 18 or older - Have either moderate to serve erosive esophatitis - Returning to Mayo Clinic Rochester for follow up endoscopy 8 weeks after start of study. Exclusion Criteria: - already on or failed omeprazole in past - intolerant to PPI therapy - will not be returning to Rochester Mayo Clinic in 8 weeks for clinical endoscopy. - Can not read to blindness, cognitive dysfunction


NCT ID:

NCT00693225


Primary Contact:

Principal Investigator
Yvonne Romero, M.D.
Mayo Clinic


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55901
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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