Compare the percent of subjects with moderate/severe esophagitis who achieve complete
endoscopic resolution after 8 weeks of treatment morning vs. bedtime.
Hypothesis: The timing of administration of omeprazole/sodium bicarbonate (Zegerid) will
impact nocturnal esophageal acid exposure and healing of esophagitis. Specifically, we
hypothesize that omeprazole/sodium bicarbonate, taken at bedtime, will be superior in
healing esophagitis compared to omeprazole/sodium bicarbonate taken in the morning.
Specific Aim: Compare the percent of subjects with moderate/severe esophagitis who achieve
complete endoscopic resolution after 8 weeks of treatment (morning vs. bedtime).
- Age 18 or older
- Have either moderate to serve erosive esophatitis
- Returning to Mayo Clinic Rochester for follow up endoscopy 8 weeks after start of
- already on or failed omeprazole in past
- intolerant to PPI therapy
- will not be returning to Rochester Mayo Clinic in 8 weeks for clinical endoscopy.
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