Expired Study
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Rochester, Minnesota 55902


Purpose:

Arthritis of the base of the thumb is a common debilitating problem. It is believed that laxity (loosening) of the joint leads to worsening arthritis in this joint. This can be treated by securing the joint surgically or symptoms can be treated with hand therapy and/or injection of corticosteroids. Recently prolotherapy (sugar water) has been shown to decrease looseness of joints and also be helpful for hand and knee arthritis. We hypothesize that prolotherapy injections for thumb arthritis will be equally or more beneficial to the patients then steroids.


Study summary:

This will be a prospective randomized double blind comparison study comparing Celestone to Dextrose intra-articular injections as adjuncts to hand therapy for the treatment of symptomatic thumb CMC osteoarthritis. Twenty patients will be randomized to each treatment arm to provide enough power to show a 20% change in visual analogue scale (VAS) for pain to be significant. We will also be measuring analgesic use, various grip strength and upper extremity functional assessment scores.


Criteria:

Inclusion Criteria: - Age >45 - ability to make follow-up visits over the 6 month protocol - ability to give informed consent - Eaton Grad thumb carpo-metacarpal joint osteoarthritis with pain over 3/10 on visual analogue scale with symptoms present greater then 6 months. Exclusion Criteria: - Recent trauma to the hand or wrist or fractures eeen on radiographs - Eaton grade 1 or 4 joints, metabolic bone disease, recent systemic or localized infection (within last 2 weeks) - history of rheumatologic disease - allergies to injected solutions - thumb carpo-metacarpal joint injections in the prior 6 months.


NCT ID:

NCT00685880


Primary Contact:

Principal Investigator
Michael J. Gruba, M.D.
Mayo Clinic Physical Medicine & Rehabilitation Residency


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55902
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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