The purposes of this study are to identify persons with rapid-onset dystonia-parkinsonism
(RDP) or mutations of the RDP gene, document prevalence of the disease, and map its natural
Rapid-onset dystonia-parkinsonism (RDP) is a rare, movement disorder with variable
characteristics ranging from sudden onset (hours to days) of severe dystonic spasms to
gradual onset of writer's cramp. RDP has elements of both dystonia and Parkinson's
disease—two neurological diseases with motor and neuropsychological symptoms that hinder the
quality of life. An internal trigger associated with extreme physiological stress has been
reported prior to abrupt symptom onset of RDP.
This study, which is a continuation of an earlier study begun by Dr. Allison Brashear, aims
to more clearly identify the characteristics associated with RDP and to explore whether
mutations in the RDP gene are associated with atypical dystonias, Parkinson's disease, and
other movement disorders.
Physicians from around the world who suspect their patients may have RDP or other movement
disorders will send videotaped neurological assessments of their patients and blood samples
for genetic analysis.
- clinical presentation consistent with ATP1A3 disease (RDP, AHC) or confirmed
diagnosis of RDP or AHC
Allison Brashear, MD
Professor and Chair, Department of Neurology, Wake Forest University Health Sciences
Jared F Cook, MA