The AIMS study compares a methamphetamine-specific treatment intervention to a
treatment-as-usual Functional Family Therapy (FFT) approach for adolescents ages 15 to 19.
Adolescents are assigned to one of two treatment conditions: (1) 16 weeks of FFT designed to
strengthen family relationships and develop skills for helping the adolescent avoid drug
use; or (2) 16 weeks of a combination of FFT and a methamphetamine-specific intervention
involving group and individual therapy sessions; Families are assessed using questionnaires
and interviews, and adolescents participate in neuropsychological testing, before, during,
and after treatment to provide information about family functioning, the adolescent's drug
use, the adolescent's peers, and other factors that may contribute to treatment success.
Adolescents also provide urine specimens for drug screening at assessment visits. Through a
partnership with Oregon Health and Science University (OHSU), adolescents will participate
in functional magnetic resonance imaging appointments at the hospital to examine regional
brain blood flow during tasks designed to measure impulsivity and risk-taking behaviors. As
a treatment development grant, study investigators will study adolescents' acceptance of and
response to the newly developed methamphetamine-specific treatment approach.
- 15 to 19 years of age.
- Have at least one parent or parent figure willing to participate.
- Meet DSM-IV diagnostic criteria for drug-abuse or dependence, including a specific
meth use disorder.
- Reports meth use on at least 5 of the previous 90 days.
- Have contact with the parent on at least 40% of the past 90 days.
- With their parent be willing to accept randomization to one of the two treatment
- Be willing to participate in the imaging task in the fMRI pilot study.
- Have basic English competency.
- Have sufficient residential stability to permit probable contact at follow-up.
- Evidence of psychotic or organic state of sufficient severity to interfere with
understanding of study instruments and procedures.
- Have a medical or psychological condition that would preclude undergoing the fMRI
- Have a sibling who is participating in the study.