B1AS tests the hypothesis that increased vitamin B1 (thiamine) intake can repair brain
systems damaged by alcohol and help people with alcohol problems control their alcohol use.
A strong, man-made form of thiamine (Benfotiamine) is used to increase blood thiamine to
much higher levels than can be achieved using normal vitamin supplements. Drinking patterns
are examined over 6 months of continued supplement use. Men and women with a recent history
of alcohol problems are eligible to participate.
B1AS is a randomized, double-blind placebo-controlled clinical trial of the effectiveness of
Benfotiamine at reducing abusive drinking patterns in individuals with recent alcohol
problems. Subjects consume 4 tablets of Benfotiamine (600 mg) or placebo daily for 6 months.
Monthly follow-ups track alcohol use and alcohol-related problems over the 6 months. Blood
tests are also conducted to determine the frequency of an inherited abnormality in thiamine
processing that may be related to the risk of developing alcoholism.
- Problem drinking in the last 30 days
- Prolonged abstinence
- Serious medical problems