Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these
children may require surgery. In this study, researchers affiliated with the University of
Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of
hyperinsulinism that may be cured by surgery. Eligible participants in this study will have
positron emission tomography (PET) scans with F-DOPA prior to surgery.
For children with congenital hyperinsulinism (CHI), low blood sugar is caused by cells in the
pancreas that release too much insulin. Some children with CHI have these cells throughout
their pancreas; others have them located in specific areas of the pancreas. Children who have
them located in specific areas of the pancreas may be cured with surgery. F-DOPA is a
radioactive drug that may go to these very cells. F-DOPA can also be used for positron
emission tomography (or PET), an imaging technique used in nuclear medicine departments. In
this study, researchers will test the possibility of using PET with F-DOPA in the diagnosis
of children with hyperinsulinism.
- Any age, but primarily infants 0-6 months.
- Children with confirmed diagnosis of congenital hyperinsulinism.
- Cases in which surgery will not be considered by parents or guardians.