The objectives of the study are:
1. To evaluate the effect of ABT-335 (choline fenofibrate) on several parameters of RCT
(reverse cholesterol transport) in men and post-menopausal women diagnosed with
dyslipidemia (i.e., low high-density lipoprotein [HDL] cholesterol levels and elevated
triglyceride [TG] concentrations).
2. To evaluate longitudinal changes in several parameters of RCT in subjects with low HDL.
3. To obtain pilot data for power calculations for subsequent comparative study.
This trial assesses the effects of ABT-335 on RCT as measured by cholesterol efflux or rate
of appearance of cholesterol (Ra in mg/kg/hr), cholesterol excretion (%/day), RCT efflux
(mg/kg/day) and de novo cholesterol synthesis (%) during a baseline period (7 days) and
during a treatment period (94 days).
The goal of using RCT to reverse atherosclerosis is to increase the rate of cholesterol
export or "efflux" from the tissues and plaques. An increase in this cholesterol efflux rate
should shrink arterial plaques by decreasing their static accumulation of cholesterol. While
some currently marketed drugs have a positive impact on RCT by increasing the rate of
cholesterol excretion from the body, no drug has yet been approved to increase the rate of
cholesterol efflux from the tissues
1. Male, non-smoker, 21 - 75 years of age inclusive.
2. Female, non-smoker, 40 - 75 years of age inclusive.
3. Post-menopausal women, as defined by lack of menses for at least 2 years and age >
55, OR history of documented bilateral surgical oophorectomy, confirmed with an
elevated follicle-stimulating hormone (FSH) at screening.
4. HDL concentration (≤ 50 mg/dl women, ≤ 40mg/dl men)
5. TG concentration 150-500 mg/dl, inclusive
6. Ability to give informed consent
1. Subject has history of diabetes mellitus, active hepatitis, gall bladder disease,
gastric bypass surgery, or clinically significant abnormalities on screening
(prestudy) physical examination or laboratory tests.
2. Screening laboratory tests with hematocrit <30%, aspartate aminotransferase
(AST)/alanine aminotransferase (ALT) > 2X upper limit of normal, abnormal
thyroid-stimulating hormone (TSH), fasting glucose ≥126 mg/dl.
3. Renal impairment with creatinine clearance < 80 ml/min.
4. Treatment within the last 6 months with drugs known to alter lipid metabolism
including beta blockers, thiazide diuretics, bile acid resins, ezetimibe, fibrates,
niacin, and fish oils (see Appendix 1). Washout of fibrates is not permitted.
5. Treatment with drugs known to interact with ABT-335, e.g., warfarin (see Appendix 1).
6. Treatment with HMG CoA reductase inhibitors (statins) within the past 4 weeks (see
7. History of allergy to egg or soy products.
8. History of coronary heart disease (CHD), stroke or revascularization procedure in the
six months prior to Visit 1.
9. Current or recent history (past 12 months) of drug abuse or alcohol abuse. Alcohol
abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5
oz hard liquor).
10. Participation in another clinical trial or exposure to any investigational agent
within 30 days before visit 1.
11. Individual has a condition the Principal Investigator believes would interfere with
his/her ability to provide informed consent, comply with study instructions, or which
might confound the interpretation of the study results or put the subject at undue