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Rochester, Minnesota 55905


The purpose of this study is to evaluate endothelial function and autonomic regulation in smokers before and after short-term smoking cessation. We hypothesize that 2 weeks of smoking cessation will improve endothelial function as measured by flow-mediated dilation. We will also determine if endothelial function and autonomic regulation after short-term smoking cessation differs for patients that achieve abstinence with the smoking cessation agent varenicline compared to placebo.


Inclusion Criteria: - Regular smokers (currently >10 cigarettes/day; >5 pack years) - Willing to quit smoking for at least the duration of the study - Able and willing to give written informed consent Exclusion Criteria: - Known condition causing endothelial dysfunction except smoking (i.e. diabetes, hyperlipi¬demia, arterial hypertension, obesity) - Regular drug treatment and/or sporadic consumption of drugs within the last 4 weeks (exclusion has to be decided in each individual) - Acute or chronic illness - Participation in clinical trial within 1 month before the study - Excessive daily intake of alcohol (>2 servings per day) or caffeine (>4 servings/day) - Drug and/or alcohol abuse.



Primary Contact:

Principal Investigator
John H Eisenach, M.D.
Mayo Clinic

Backup Contact:


Location Contact:

Rochester, Minnesota 55905
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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