The purpose of this study is to find ways to improve wound healing and decrease the negative
effects of trauma from burn injury.
This study involves research and the investigators hope to learn the following: how or what
effect one or more anabolic ("tissue building") agents have on muscle metabolism, wound
healing, and immune function after severe burn. The agents include the following: growth
hormone, insulin-like growth factor-1 in combination with its binding proteins, insulin,
Beta-adrenergic blockers, Alpha Adrenergic Agonist, anabolic steroids such as testosterone,
Oxandrolone and nandrolone, ketoconazole and its derivatives, dehydroepiandrosterone,
fenofibrate, diet or the application of skin substitute.
- Patient is between 0 and 90 years of age
- Patient 18 years and older consents to participate in study protocol. If patient is
not able to consent, consent will be obtained from closest family member or legal
guardian. Parental permission will be obtained for patients less than 18 years of
age. Assent will be obtained from children 7-17 years of age if child is
physically/mentally able to do so.
- greater than 30% TBSA burn requiring at least 1 operation with donor sites for skin
- Known history of AIDS, AIDS-related complex, Human Immunodeficiency Virus
- History of cancer within 5 years
- Tuberculosis, arthritis, cirrhosis, hyperlipidemia, bone or endocrine diseases,
- Chronic glucocorticoid or non-steroidal anti-inflammatory drug therapy