The purpose of this study is to find a safe dose of actinium-225 when it is labeled to
HuM195. This will be done with a "phase I trial," in which a preset schedule of doses gets
more powerful for each new group of patients as the trial progresses. If too many serious
side effects are seen with a certain dose, no one will be treated with a higher dose, and
some additional patients may be treated with a lower dose to make sure that this dose is
safe. The starting dose of actinium-225 in this study is less than doses that are known to
be safe in animals.
Antibodies are proteins that are produced by the immune system and help the body to fight
foreign substances, such as bacteria or viruses. HuM195 was made by putting human leukemia
cells into mice. Most of the mouse parts of this antibody were replaced with human parts.
Only the part of the antibody that binds to the leukemia cells was kept from the mouse.
HuM195 attaches to leukemia cells but does not attach to most normal cells. It can kill
small amounts of disease by identifying the leukemia cells as "foreign." HuM195 has worked
less well against large amounts of leukemia since the normal immune cells needed to kill
leukemia cells are lowered in most patients with leukemia.
- Patients must have one of the following pathologically confirmed diagnoses:
- AML in relapse,
- AML refractory to at least 2 courses of standard induction chemotherapy or one course
of high-dose cytarabine-containing induction chemotherapy,
- CML in accelerated phase or myeloid blast crisis that has progressed after treatment
with imatinib and a second generation tyrosine kinase inhibitor (e.g., dasatinib or
- RAEB with International Prognostic Scoring System (IPSS) score ≥ 2.5, or - CMMOL with
IPSS score ≥ 2.5 refractory to or relapsed after a hypomethylating agent (e.g.,
azacitidine or decitabine) refractory to or relapsed after a hypomethylating agent
(e.g., azacitidine or decitabine).
- Greater than 25% of bone marrow blasts must be CD33 positive.
- Patients must have a life expectancy of at least 6 weeks and a Karnofsky performance
status of ≥ 60%.
- Adequate renal function as demonstrated by a serum creatinine ≤ 1.5 mg/dl, a
creatinine clearance > 60 ml/min, and < 1 gram urinary protein/24 hours.
- Adequate hepatic function as demonstrated by a bilirubin ≤ 1.5 mg/dl (unless
attributable to leukemia or Gilbert's disease) and alkaline phosphatase and AST ≤ 2.5
times the upper limit of normal.
- Untreated AML, regardless of prognostic features.
- Treatment with chemotherapy or biologic therapy within 3 weeks of 225Ac- HuM195
administration. Hydroxyurea is permitted but must be discontinued prior to treatment
on study. Patients must have recovered from the effects of previous treatment.
- Treatment with radiation therapy within 6 weeks of 225Ac-HuM195 administration.
Patients must have recovered from the effects of previous treatment.
- Active serious infections not controlled by antibiotics.
- Pregnant women or women who are breast-feeding.
- Concurrent active malignancy requiring therapy.
- Clinically significant cardiac disease (NY Heart Association Class III or IV)or
- Patients with HLA-compatible donor bone marrow who are immediate candidates for bone
- Patients who are candidates for alternative treatments of known effectiveness.
- Patients eligible for protocols of higher priority.
- Patients previously treated with any monoclonal antibody for any reason.
- Active CNS leukemia
- Other serious or life-threatening conditions deemed unacceptable by the principal