RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
Bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for
cell growth. Giving paclitaxel together with bortezomib may kill more tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of paclitaxel and
bortezomib in treating patients with metastatic or unresectable malignant solid tumors.
- To identify the maximum tolerated dose of paclitaxel in combination with bortezomib in
patients with metastatic or unresectable solid tumor malignancies that involve an
activated Ras/Raf/MAPK pathway.
- To assess the toxicity of this regimen.
- To assess tumor response in these patients.
- To determine whether Bim is upregulated in peripheral blood mononuclear cells obtained
from patients treated with this regimen.
- To correlate markers of Ras/Raf/MAPK pathway activation in fresh or archived tumor
tissue with clinical response in these patients.
- To perform pharmacokinetic (PK) studies to determine whether bortezomib alters
paclitaxel PK parameters.
OUTLINE: Patients receive paclitaxel IV over 1 hour and bortezomib IV on days 1, 8, and 15.
Treatment repeats every 21 days in the absence of disease progression or unacceptable
Blood samples are collected at baseline and periodically during course 1 for pharmacokinetic
and biomarker studies. Blood samples are analyzed for plasma concentrations of paclitaxel by
high performance liquid chromatography and for Bim protein levels and phosphorylation status
by western blotting. Tumor tissue samples, if available, are analyzed to evaluate the
presence of an activated Ras/Raf/MAPK pathway. Tumor tissue samples are analyzed for Ras
and/or Raf mutations by nucleic acid extraction and direct sequencing; Ras and/or Raf
overexpression by western blotting; Ras activation assay; and/or phospho-ERK by western
blotting and IHC.
- Histologically confirmed malignant solid tumor that involves an activated
Ras/Raf/MAPK pathway, including the following:
- Breast cancer
- Prostate cancer
- Colon cancer
- Pancreatic cancer
- Ovarian cancer
- Non-small cell lung cancer
- Papillary thyroid cancer
- Metastatic or unresectable disease
- Standard curative or palliative measures do not exist or are no longer effective
- No newly diagnosed, untreated, or uncontrolled brain metastases
- ECOG performance status 0-2
- ANC ≥ 1,500/μL
- WBC ≥ 3,500/μL
- Platelet count ≥ 100,000/μL
- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)
- AST/ALT ≤ 2.5 times ULN (≤ 5 times ULN for tumor involvement of the liver)
- Creatinine ≤ 2 times ULN
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No neuropathy ≥ grade 1 with pain within the past 14 days
- No active infections
- No myocardial infarction within the past 6 months
- No NYHA class III or IV heart failure
- No uncontrolled angina
- No severe uncontrolled ventricular arrhythmias
- No evidence of acute ischemia or active conduction system abnormalities by ECG
- Any ECG abnormality at screening must be documented by the investigator as not
- No hypersensitivity to bortezomib, boron, or mannitol
- No serious medical or psychiatric illness likely to interfere with study
PRIOR CONCURRENT THERAPY:
- Prior paclitaxel or bortezomib allowed
- At least 4 weeks since prior chemotherapy and/or radiotherapy
- More than 14 days since other prior investigational drugs
- No other concurrent investigational agents
- No other concurrent anticancer agents, including chemotherapy and biologic agents
- No concurrent recombinant interleukin-11 (Neumega®)