Opioid medications are commonly used for pain relief. When given over time, physical
dependence can occur. This results in unpleasant side effects--such as agitation and
nausea--if opioid medications are suddenly stopped. We are interested in knowing if a
medication named Ondansetron can help ease or prevent symptoms associated with opioid
withdrawal. We are also interested in knowing if a similar (but more potent FDA-approved
drug, palonosetron) can more effectively treat withdrawal symptoms with or without
combination with an antihistamine called hydroxyzine (vistaril).
We hope to learn if Ondansetron, Palonosetron, and/or combination with hydroxyzine can be
used to prevent or attenuate the signs and symptoms of opioid withdrawal. If we find that it
can help prevent these symptoms, it may become a new treatment that can aid patients
suffering from these symptoms.
- healthy men
- ages 18-35
- history of substance abuse
- Raynaud's disease or coronary artery disease