Expired Study
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St. Louis, Missouri 63110


To assess the feasibility of administering induction chemotherapy with gemcitabine and docetaxel followed by concurrent radiation and continuous infusion 5FU and consolidation gemcitabine/docetaxel chemotherapy.


Inclusion Criteria: - Patients must have biopsy-proven, resected with curative intent cholangiocarcinoma, gallbladder, pancreatic or ampullary adenocarcinoma. - Patients must be 18 years or older. - Patients must have a NCI CTC Performance Status of 0-2. - Patients must not have any prior chemotherapy or radiation therapy for this current malignancy. - At least 3 weeks should have elapsed since any surgery requiring general anesthesia. - Patients must have no prior malignancies except for basal or squamous skin cancers, cervical carcinoma-in-situ, unless in remission for >5years - Pregnant patients are not eligible. Non-pregnant status will be determined in all women of childbearing potential. All patients will be required to use an effective means of contraception if sexually active during therapy. - Initial Required Laboratory Values: - Absolute neutrophil count ≥ 1,500/mm3, platelet count ≥ 150, 000/mm3, and hemoglobin ≥ 9 g/dL. - Serum creatinine should be ≤ 2 mg/dL. - Serum bilirubin should be ≤ 3.0 mg/dL (biliary stents allowed). - Serum transaminases should be ≤ 5-fold the institutional upper limits. - Patients must not have any co-existing severe medical illnesses, such as unstable angina, uncontrolled diabetes mellitus, uncontrolled arrhythmia or uncontrolled infection. - Patients must be able to sign an informed consent. Exclusion Criteria: - None



Primary Contact:

Principal Investigator
Benjamin Tan, M.D.
Washington University School of Medicine

Backup Contact:


Location Contact:

St. Louis, Missouri 63110
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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