The purpose of this research study is to assess whether seeing other people itch affects
itch perception in patients with atopic dermatitis and healthy subjects.
The objectives of this study are to quantitatively assess the effect of visual stimuli on
perception of itch and to assess if visual stimuli affect individuals with atopic dermatitis
differently than healthy people.
- Adult men and women who are between 18 and 65 years of age
- Diagnosis of moderate to severe atopic dermatitis including involvement of the
forearm confirmed by published consensus diagnostic criteria35 (except for healthy
control subjects). Severity of AD will be based on an investigator's global
assessment score (IGA).
- Subjects must be in general good health with no other skin disease, disease state or
physical condition which would impair evaluation of their skin or which would
increase their health risk by study participation
- Women of child bearing potential will be required to have a negative pregnancy test
in order to enroll in the study and will be required to maintain adequate birth
control throughout the study.
- All subjects in Groups 1 and 3 will be required to cease use of oral antihistamines
for a period of one week prior to and during the study visit.
- Subjects in Groups 1 and 3 must cease using topical agents on the forearm where
experimentation is going to be performed at least 1 week prior. Topical agents can be
used in all other parts of the body.
- Baseline COVAS ratings of more than 9/100 after histamine iontophoresis at the
- Adults over age 65
- Children less than 18 years of age
- Unable to complete the required measures
- Currently enrolled in any investigational study in which the subject is receiving any
type of drug, biologic, or non-drug therapy and subjects undergoing treatment with
another investigational drug or approved therapy for investigational use within 28
days prior to study participation
- Consumption of more than 4 caffeinated beverages per day
- Current treatment with oral lipophilic beta blockers, opioids, glucocorticoids,
theophylline, antihistamines or other medications known to interfere with itch
perception or heart rate variability as determined by the investigators
- Uncontrolled asthma or COPD
- Uncontrolled thyroid disease
- Poorly controlled diabetes mellitus
- Poorly compensated congestive heart failure
- Use of illicit drugs
- History of chronic urticaria
- History of anaphylactic shock
- History of neuropathy causing disease such as diabetes and uremia
- Allergy to histamine
- Baseline COVAS ratings of less than 9/100 after histamine iontophoresis at the
- Subject participation in more than one group.
- Positive pregnancy test