Expired Study
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Loma Linda, California 92357


Purpose:

Hypothesis for this pilot study is that simvastatin will lower the levels of CRP and ET-1 in COPD patients.


Study summary:

Patients with chronic obstructive lung disease (COPD) have an ongoing systemic inflammation, which can be assessed by measuring C-reactive protein (CRP). CRP is found to be a strong and independent predictor of future COPD outcomes. Statins are a class of cholesterol lowering drugs that decrease mortality from cardiovascular disease and stroke. In addition, they have anti-inflammatory, anti-thrombotic and immunomodulatory properties. Statins lower C-reactive protein by the ability to reduce the production of interleukin (IL)-6, the cytokine that activates the acute phase CRP response. Thus the rationale for this study is to evaluate effect of statins on the levels of CRP and ET-1 in COPD patients.


Criteria:

Inclusion Criteria: - Medically optimized COPD patients - Age 40-79 years. - serum CRP levels >3mg/l Exclusion Criteria: - Current smoker - COPD exacerbation in the last 2 months. - Active hepatic or severe renal dysfunction. - connective tissue disease, chronic inflammatory disease, malignancy, any acute illness, leukocytosis (>10,000 white blood cells) or thrombocytosis (>450,000 platelets). - Recent h/o myocardial infarction, angina in the last 6 months. - Pregnancy.


NCT ID:

NCT00655993


Primary Contact:

Principal Investigator
Lennard Specht, M.D.
VA Loma Linda Health Care System

Hemal J. Parekh, M.D.
Phone: 909-825-7084 ext. 6098
Email: hemalp6@yahoo.com


Backup Contact:

Email: norman.specht@va.gov
Lennard Specht, M.D.
Phone: 909-825-7084 ext. 6098


Location Contact:

Loma Linda, California 92357
United States

Lennard Specht, M.D.
Phone: 909-825-7084
Email: norman.specht@va.gov

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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