The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide,
and promethazine for the treatment of nausea in the adult emergency department population.
We hypothesize that a single intravenous dose of ondansetron is more effective in reducing
nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in
undifferentiated adult emergency department patients.
- All patients age 18 or older who present to the ED with a complaint requiring
antiemetic treatment who do not meet the exclusion criteria.
- Patients less than 18 years of age
- Unstable patients with SBP < 90
- Patients with a stated or documented allergy to any of the study medications
- Patients whose nausea rating if < 40 on the pretreatment VAS scale
- Patients who have received a commonly accepted antiemetic within the previous 24
- Patients unwilling or unable to complete the assessment tool before and 30 minutes
after study drug dosing