At the time of hysterectomy for benign disease, the overall health benefits of preserving
ovarian function in a large population of women have not been established.
We are conducting a prospective, observational study of 32,175 women participants of the
Nurse's Health Study who had a hysterectomy with or without removal of both ovaries. We are
evaluating mortality and morbidity due to the following conditions: coronary heart disease,
stroke, breast cancer, ovarian cancer, other cancer, hip fracture and death from all causes.
- Women who had hysterectomies were classified into simple hysterectomy or hysterectomy
with both ovaries removed.
- Evidence of cancer, coronary heart disease (MI or Angina Pectoris), stroke, or hip
fracture before entering the study were excluded. Cancer as an indication for
hysterectomy also excluded.
- Women reporting unilateral oophorectomy, unknown oophorectomy status, unknown age of
hysterectomy, or those who had oophorectomy before hysterectomy were excluded.