The aim of our study is to assess the effect of daily consumption of yogurt containing
probiotic bacteria BB12 on the health and growth of healthy children 12-48 months of age in
out of home child care.
- An informed consent has been signed by the parents.
- The child is at least one year old and has not had his 4th birthday at the
beginning of the study
- The child is healthy.
- The child attends child care center at least 5 days a week, > 4 hours per day.
- Was born preterm.
- Had a birth weight <2,500 g.
- Has congenital anomalies.
- Has a structural abnormality of the digestive tract or previous significant
- Has chronic disease or malignancy.
- Has a serious, unstable medical condition.
- Is Failure to Thrive (FTT) (<5th percentile of ideal body weight).
- Has an allergy or atopic disease.
- Has an allergy or intolerance to milk/dairy products.
- Has an established diagnosis of lactase deficiency.
- Is predisposed to infection (i.e., compromised immune system, HIV-AIDS, active
bacterial disease, under steroid treatment).
- Received antibiotic treatment or intentionally consumes probiotic products during the
preceding 4 weeks. (If the subject was on antibiotics before the beginning of the
study or probiotics, a washout period of 2 weeks is required.)
Tamar Ringel-Kulka, MD, MPH
University of North Carolina, Chapel Hill