Experiment in the test tube indicated that CP-945,598 becomes less soluble with increase of
pH (less acidity). Changes in stomach acid levels may affect the solubility of CP-945,598,
therefore, alters its availability in the blood. Omeprazole decreases acid levels in
stomach. This study will compare the time course of drug concentrations in the body,
safety, and tolerability of CP-945,598 given with and without omeprazole.
- Body Mass Index (BMI) of 26.6 to 40.5 kg/m2.
- Non-prescribed use of drugs or abuse of recreational drugs; recent treatment with
experimental drugs or herbal experiments; EKG and blood pressure measurements falling
outside of protocol-specified limits; history of regular alcohol or tobacco use
exceeding protocol-specified limits; medically important health conditions; recent
use of prescription or non-prescription medications.