The purposes of this study are to determine if the performance of a dialyzer depends on how
tightly the hollow fiber membranes are packed in the housing of the dialyzer (the membrane
packing density) and if that dependence is a function of the dialysate flow rate. The study
will examine how efficiently three different sized molecules pass through a dialyzer
membrane at different dialysate flow rates in dialyzers with different membrane packing
densities. Transfer of urea, phosphorus and beta-2-microglobulin from blood to dialysate
will be measured during clinical hemodialysis using four different dialyzers, each used at
three different dialysate flow rates. The data derived from these measurements may provide
insight into the importance of membrane packing density as a design parameter for
hemodialyzers and if changing the membrane packing density might provide equivalent
performance at a lower dialysate flow rate.
- Stable hemodialysis patients dialyzing through a native fistula or Gore-Tex graft.
The access must be capable of delivering a stable blood flow of 400 ml/min.
- Age older than 18 years.
- Fluid removal requirement less than 3 liters per treatment.
- Noncompliance with dialysis regimen.
- Hematocrit less than 28%.
- Active infection