Expired Study
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Belmont, Massachusetts 02478


Purpose:

This study investigates the hypothesis that instability in mood in patients with borderline personality disorder will respond the mood stabilizing medication lamotrigine.


Study summary:

Affective instability is one of the most prominent symptoms in borderline personality disorder. Currently there are no prospective studies of treatment of this symptom with mood stabilizing medications. This study examines the effectiveness of lamotrigine compared to placebo in reducing emotional instability of several types in borderline patients. The types of emotional instability studied involve anger, anxiety, depression, and elation. Subjects entering this 12 week study will be blind to whether they are receiving active medication or placebo. They will be asked to report levels of instability in their mood on a weekly basis. They will also be asked weekly to rate the intensity of other symptoms of borderline personality disorder symptoms, such as unstable relationships, self-harm, and impulsive behaviors.


Criteria:

Inclusion Criteria: - Clinical Diagnosis of Borderline Personality Disorder with high levels of emotional instability Exclusion Criteria: - Clinical diagnosis of Bipolar Disorder - Clinical diagnosis of psychiatric disorder related to general medical condition - Clinical diagnosis of substance abuse disorder within the last 60 days - Clinical diagnosis of psychotic disorder - Previous treatment with lamotrigine - Pregnancy or nursing - Currently hospitalized - Active suicidal or homicidal ideation


NCT ID:

NCT00634062


Primary Contact:

Principal Investigator
D. Bradford Reich, M.D.
Mclean Hospital


Backup Contact:

N/A


Location Contact:

Belmont, Massachusetts 02478
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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