This project is aimed at determining whether an exercise-based weight loss intervention
causes a compensation in some component of energy expenditure such that the increase in
measured energy expenditure is less than the added exercise. The study will compare two
separate exercise interventions to determine if this is influenced by exercise intensity.
The primary aim of this proposed study is to determine how total daily activity
thermogenesis (TDAT) and total daily energy expenditure (TDEE) are regulated in obese humans
attempting to lose weight and maintain weight loss through exercise. Two exercise
interventions will be compared; a structured aerobic exercise program and a walking program.
EAT will be verified, and NEAT, TDAT, and TDEE will be measured using state-of-the-art
technologies. Subjects will be studied during a 6 month intervention period and then during
a 6 month follow-up period. It is hypothesized that the walking program will have more
favorable effects on TDAT and TDEE during both the intervention and follow-up periods. If
our hypotheses are correct, then data from the proposed study could be used to improve the
effectiveness of exercise-based weight loss and weight loss maintenance programs.
- Body mass index (BMI) 30-35.0 kg/m2
- Age 18-45 years
- Weight stable (<2 kg weight fluctuation during previous 6 months)
- No regular exercise (> 1 bout of exercise/wk or participation in any sporting
activities > 1 hr/wk)
- No self-report of acute or chronic disease (diabetes, heart diseases, and joint
problems in particular)
- No current use of prescribed medications
- No plans to relocate within the next year
- No plans for extended travel (> 1 week) within the next 6 months
- No tobacco use
- For females
- No evidence of amenorrhea (Regular menstrual cycles of 21-35 days)
- Pre-menopausal status (self-report, to be confirmed during screening)
- Pregnancy or lactating within the past year
- No pregnancy or planned pregnancies; sexually active women of childbearing
potential may be enrolled if they have had a tubal ligation or use one of the
following means of contraception: condom, diaphragm, oral or implanted
contraceptives, or intrauterine device. Women in exclusive relationships with
male partners who have had a successful vasectomy will not be required to use
any additional means of birth control.
Conditions that do not meet the Inclusion Criteria listed.
Edward Melanson, PhD
University of Colorado Division of Endocrinology, Metabolism, and Diabetes/Division of Geriatrics