Researchers have previously demonstrated loss of heterozygosity in a region on chromosome
18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used
in this study are specifically described by those authors as showing loss of heterozygosity
in 6 of 7 affected families.
As above, no additional information
- This is a familial study therefore the only inclusion/exclusion criteria would be
that subjects must be a blood relative and over the age of 18.
- The subjects are proband and father along with unaffected blood relatives. Their
peripheral blood will act as a control and provide information to delineate the
inheritance from the father, as seen in the son.
- Not part of the family