A form of irregular heart rate called, Atrial Fibrillation (AF) is a major clinical problem.
It afflicts about 2 million Americans and is the single largest heart related cause of
stroke. However, despite 120 years of speculation and research, the mechanisms that cause AF
are poorly understood. Acute AF is also the most common irregular heart rate after
open-heart surgery in patients. This is seen in as many as 30% of such patients and often
results in a longer hospital stay.
In this study we would like to study the pattern of atrial fibrosis (scar tissue in the
heart) and an associated blood marker (a protein called pro-collagen-1) in those patients
concurrently having open heart surgery.
1. 18 years of age, Male or Female
2. Able to provide consent
3. Cardiac surgery, CABG of Valve replacement or repair.
1. If AF terminates within 1 hour of initiation.
2. If the patient undergoes electrical cardioversion and/or receives digitalis within
the first hour of inclusion.
3. If the patients and/or their family or the primary caregiver choose to be excluded
from the study anytime, even after the initial 24-hour period.
4. If the patient expires within 1 hour of inclusion into the study. -