Expired Study
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West Haven, Connecticut 06516


Purpose:

This study investigates the interactions between NMDA (N-Methyl-D-aspartic acid) antagonism and GABA (gamma-aminobutyric acid) system as it relates to cognitive function assessed by ERPs (event-related potentials) in healthy volunteers.


Criteria:

Inclusion criteria: - Ages of 21-45 years from all ethnic backgrounds. - Male or female. - Written informed consent. Exclusion criteria: - DSM-IV diagnosis for a psychotic, depressive or anxiety disorder. - A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic abnormality, seizure disorder. Unstable medical condition based on EKG, vital signs, physical examination and laboratory work-up (CBC with differential, SMA-7, LFTs, TFTs, UA, Utox). - History of abnormal EEG. - History of severe allergies or multiple adverse drug reactions. - Any medication that could interfere with either the safety of the study and/or the outcome measures. - Any other conditions which in the opinion of the investigator would preclude participation in the study. - History of major psychiatric disorder in first degree relatives. - Current substance abuse/dependency determined by urine toxicology. - Treatment with medications with CNS effects. - Treatment with benzodiazepines within one week prior to testing. - Current treatment with medications with psychotropic effects. - Education < 10th grade. - IQ < 70, MR. - Non-English speaking.


NCT ID:

NCT00611572


Primary Contact:

Principal Investigator
Handan Gunduz-Bruce, M.D.
Yale School of Medicine, Assistant Professor


Backup Contact:

N/A


Location Contact:

West Haven, Connecticut 06516
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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