Expired Study
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Philadelphia, Pennsylvania 19104


Purpose:

GSK598809 is being developed as an innovative treatment for substance dependence and potentially other compulsive behavioral disorders. This study will asses the effects of a single dose of GSK598809 in modulating nicotine reward in 2 cohorts of otherwise healthy male volunteers who smoke. Each cohort of subjects will receive a single dose of placebo or GSK598809 in two dosing sessions binded crossover fashine. There will be a washout period of at least seven days between each session.


Criteria:

Inclusion Criteria: - Healthy male smokers aged 18-65 with a desire to quit smoking. - Body weight greater than 50kg and BMI within range 19 - 29.9 kg/m2 - Healthy with no significant medical, psychiatric or laboratory evaluation abnormality. Exclusion Criteria: - Positive pre-study urine drug/breath alcohol screen: positive HIV 1/2, Hepatitis B or Hepatitis C test at screening. - History of alcohol/drug abuse or dependence (other than nicotine) within 12 months of the study. - History of psychiatric disorder or sensitivity to any of the study medications or components thereof or a history of drug or allergy that in the opinion of the physician responsible contraindicates their participation. - History of cardiac or pulmonary disease/abnormalities.


NCT ID:

NCT00605241


Primary Contact:

Study Director
GSK Clinical Trials
GlaxoSmithKline


Backup Contact:

N/A


Location Contact:

Philadelphia, Pennsylvania 19104
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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