In cooperation with Merck & Co, Inc. we will identify and form a database of 35 patients who
have developed osteochemonecrosis of the jaws related to oral bisphosphonate use. We will
study the triggers, associated medical conditions and medications, location of the
lesion(s), and patient outcomes.
This study is an observational study, and not a comparative trial. The major outcome is
represented by the fraction of subjects with long term healed lesions.
- Exposed bone in the oral cavity of greater than 6-8 weeks duration unresponsive to
- Pregnant patients
- Patients less than 30 yrs of age or greater than 90 yrs of age
- Mentally incompetent individuals