Nashville, Tennessee 37232


Purpose:

Correlation of cerebrospinal fluid levels of transforming growth factor beta-1 with functional improvements after insertion of ventriculoperitoneal shunt for normal pressure hydrocephalus


Study summary:

The goal of this research is to investigate a potential CSF biomarker of NPH as a new tool for both the diagnosis of NPH and prognosis of VPS placement. Transforming growth factor-b1 (TGF-b1) is a signaling molecule involved in three fundamental activities; suppression of cell proliferation, immunosuppression, and deposition of extracellular matrix through promotion of synthesis and inhibition of degradation.8 Previously, TGF-b1 had been implicated in the development of communicating hydrocephalus secondary to pre-term infant intraventricular hemorrhage9 and adult aneurysmal sub-arachnoid hemorrhage.10, 11 Recently, an investigation demonstrated elevated levels of TGF-b1 in patients with shunt-responsive NPH compared to non-NPH patients.12 The specific aims of this research proposal are to: 1. Correlate CSF levels of TGF-b1 with the clinical response of patients diagnosed with NPH to VPS placement. 2. Correlate CSF levels of TGF-b1 with optimal VPS pressure settings.


Criteria:

Inclusion Criteria: - Diagnosis of Normal Pressure Hydrocephalus Exclusion Criteria: - Patients not diagnosed with Normal Pressure Hydrocephalus


NCT ID:

NCT00600795


Primary Contact:

Principal Investigator
Noel Tulipan, M.D.
Vanderbilt University

Noel Tulipan, M.D.
Phone: 615-322-6875
Email: noel.tulipan@Vanderbilt.Edu


Backup Contact:

Email: mayshan.ghiassi@Vanderbilt.Edu
Mayshan Ghiassi, M.D.
Phone: 615-322-1053


Location Contact:

Nashville, Tennessee 37232
United States



There is no listed contact information for this specific location.

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.