Expired Study
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Little Rock, Arkansas 72202


Purpose:

This is a study in which increasing amounts of peanut flour are given to the children who are peanut allergic to desensitize them to peanut. The hypothesis is that the peanut allergic patients would benefit from the desensitization by assuring that they will not have life-threatening allergic reactions to contaminating amounts of peanut in other foods and eventually it would cause them to lose their clinical sensitivity to peanut.


Study summary:

Peanut allergy is one of the most serious of the immediate hypersensitivity reactions to foods in terms of persistence and severity of the reaction and appears to be a growing problem. Due to the persistence of this reaction and the lack of effective treatment, allergen-specific immunotherapy (IT)using the oral route of ingestion is currently being examined as a treatment option. An understanding of the molecular mechanisms of peanut-specific IT is vital to ensure the eventual, successful treatment of peanut-allergic patients. This study will examine not only the child's response to the oral peanut flour but will also examine the changes in the immunological system which is responsible for the peanut allergy.


Criteria:

Inclusion Criteria: - Subjects between 1 and 16 years of age - Diagnosed peanut allergy by either: 1) a positive prick skin test to peanuts, CAP FEIA of 15 or greater and a history of significant clinical symptoms within one hour after ingestion of peanuts or 2) a positive prick skin test to peanuts, CAP FEIA of ≥ 7 and a history of a clinical reaction to peanut ingestion within the past 6 months. - A family that will be able to be compliant with all study visits Exclusion Criteria: - Subjects with a history of severe anaphylaxis to peanut - Subjects with a medical history that would prevent a DBPCFC/OFC to peanut - Subjects unable to cooperate with challenge procedures or unable to be reached by telephone for follow-up


NCT ID:

NCT00598039


Primary Contact:

Principal Investigator
Wesley Burks, MD
University of North Carolina, Chapel Hill


Backup Contact:

N/A


Location Contact:

Little Rock, Arkansas 72202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 21, 2018

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