A correlation between obesity and male fertility has been observed in a few clinical
studies. Normal weight men appear to have higher sperm concentrations and sperm motility
when compared to obese men, suggesting that weight loss might improve sperm function.
However, there also are reported cases of severe male factor infertility following weight
loss surgery in previously fertile men. The aim of this study is to determine if there are
differences in the semen analyses and hormone levels of men obtained before and after
undergoing weight loss (bariatric) surgery.
This will direct future research and treatment.
We will recruit 60 subjects for this study. Volunteers will provide pre-operative semen and
blood samples prior to undergoing weight-reduction surgery.
Those with normal pre-operative sperm samples will be invited to continue participating in
the study by providing subsequent post-operative semen samples and hormonal testing over a
two year time period.
It is estimated to take approximately one year to enroll the desired 60 subjects. The study
will conclude two years from the last enrollment.
The main analysis will be a comparison of sperm concentrations over time.
- Adult male subjects between the ages of 18-65 undergoing bariatric surgery
- Subjects with abnormal sperm analysis