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Rochester, New York 14642


The purpose of this study is to better understand the reason why people with injuries to their knee meniscus(cartilage) are at a higher risk for osteoarthritis later in life.

Study summary:

After arthorscopic meniscal surgery, some patients develop arthritis over the following one or two decades, while others do not. We have identified a gene which may become "turned on" in the cartilage of the knee joint after an injury and which may cause cartilage deterioration. The degree to which this happens in different individuals may determine who is at risk for arthritis after meniscal injury. Thus we hope to develop tests to identify individuals at high risk at the time of injury so that preventative meaures might be taken to decrease their chance of developing arthritis. Patients who participate in the study will undergo standard arthroscopy procedures and will be followed for a longer time period than typical patients. Participants will have MRI scans a month after surgery and 3 years postoperatively, in addition to routine annual clinic visits and radiographs during the 3 year follow-up period.


Inclusion Criteria: - Isolated medial meniscus tear - Age range 20-50 years old - Male or female, any race - Tear type: mid to posterior horn, medical meniscus - Time from injury/onset of symptoms < 6 months - Failure of conservative management of symptoms - Mental status consistent with completing protocol Exclusion Criteria: - Chronic symptoms > 6 months - Body Mass Index > 30 - Avascular necrosis or osteochondritis dissecans by MRI - Peri-articular fracture by MRI - Presence of metal hardward about the knee - Severe claustrophobia - Knee ligament injury or instability of affected knee - Evidence of osteoarthritis on standing radiographs - Meniscal resection at arthroscopy at >50% - Inflammatory Joint Disease - History of allergy to MRI gadolinium contrast agent - Standard contra-indicationf to MRI - Varus knee deformity on plain standing AP radiograghs - Pregnancy - History of acute or chronic renal insufficiency of any severity (Creatinine levels >1.0 mg/dL; Glomerular Filtration Rate <60 mL/min/1.73m3)



Primary Contact:

Principal Investigator
Randy Rosier, MD, PhD
University of Rochester

Backup Contact:


Location Contact:

Rochester, New York 14642
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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