Expired Study
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Indianapolis, Indiana 46202


Purpose:

The purpose of this study is to compare the effects (good and bad) of the medication basiliximab in combination with cyclosporine with cyclosporine alone for the prevention of graft-versus-host disease. This research is being done because there is no completely safe and effective prevention for graft-versus-host disease. It is known that cyclosporine helps with GVHD but we would like to know if the addition of basiliximab will decrease the incidence and/or severity of GVHD after a transplant known as nonmyeloablative ("mini" transplant).


Criteria:

Inclusion Criteria: - Acute myelogenous leukemia, Acute lymphocytic leukemia, Chronic myelogenous leukemia, Chronic lymphocytic leukemia, Myelodysplasia, Non-Hodgkin's Lymphoma, Mantle cell, Hodgkin's Disease, Multiple Myeloma, Myelofibrosis with disease-specific eligibility requirements as outlined in the protocol - Donor Requirement: Must have a fully HLA-matched (10 of 10) related or unrelated donor, eighteen years of age or older, who is capable of undergoing GCSF mobilization and apheresis. Exclusion Criteria: - Active CNS disease (the presence of leukemic blasts in the CSF) - Pregnancy or breast-feeding - SGOT >3x upper limit of normal - Creatinine >2 or creatinine clearance <50cc/hr. - Fractional shortening by echocardiogram not within normal limits per institution - Pulmonary function: DLCO less that 50% of normal predicted, corrected for anemia - Prior allogeneic transplant


NCT ID:

NCT00594308


Primary Contact:

Principal Investigator
Robert Nelson, MD
Indiana Universtiy School of Medicine


Backup Contact:

N/A


Location Contact:

Indianapolis, Indiana 46202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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