1. Bisphosphonate-associated osteonecrosis of the jaw(ONJ)is detectable by positron
2. Bisphosphonate-associated ONJ can be diagnosed and characteristically differentiated
from other bony pathologies of the jaw(osteomyelitis, osteolytic lesions, and
osteoradionecrosis)by PET imaging.
Is to review medical records of approximately 1000 patients with bisphosphonate-associated
ONJ who have had PET imaging at the time of diagnosis. Also to review medical records of
patients who have been diagnosed with jaw osteomyelitis, osteoradionecrosis, and cancerous
lytic lesions who received PET imaging at the time of diagnosis.
If sufficient information regarding presentation and treatment cannot be obtained form the
medical record, approximately 300 patients will contacted by mail (and phone if necessary)
by the PI or sub-investigators to question them regarding the onset of symptoms, treatment
interventions, and outcomes.
- Diagnosis of bisphosphonate-associated ONJ, osteomyelitis, osteoradionecrosis,and
osteolytic lesions who received PET imaging at presentation
- Anyone who has not been diagnosed with bisphosphonate-associated ONJ, osteomyelitis,
osteoradionecrosis,or osteolytic lesions who received PET imaging at presentation