Expired Study
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Boston, Massachusetts 02114


Purpose:

The primary purpose of this study is to determine if the administration of a higher dose would decrease the chance of tumor recurrence, compared to the risk of tumor recurrence with a lower dose. Most of the treatment will be given protons, but participants may receive a small portion of treatment with x-rays, because less radiation is given to the skin with x-rays. This study uses two slightly different doses of radiation It is not clear at this time which of the dose levels is better.


Study summary:

- Participants will be assigned to a dose level by random chance, like flipping a coin. - A treatment plan will be determined by a treatment planning CT scan and will either involve 40-44 treatments or 37-40 treatments.


Criteria:

Inclusion Criteria: - Biopsy proven chordoma. Slides must be reviewed prior to randomization by the central review pathologist - Sites: Intercranial (sphenoid, clivus, petrous, basio-occiput) or cervical spine - Boost target volume less than or equal to 150 - 18 years of age or older - Karnofsky Performance Status > 50 - Neurologic Function of I or II - No evidence of metastases Exclusion Criteria: - Previous radiation to the head or neck that would compromise the ability to deliver the prescribed treatment - Concurrent or prior malignancy unless disease free for 5 or more years - Evidence of metastatic disease - Diabetes mellitus - Major medical illness or psychiatric impairments that in the opinion of the investigator, will prevent administration or completion of the protocol therapy


NCT ID:

NCT00592748


Primary Contact:

Principal Investigator
Norbert J. Liebsch, MD
Massachusetts General Hospital


Backup Contact:

N/A


Location Contact:

Boston, Massachusetts 02114
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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