Expired Study
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Atlanta, Georgia 30322


Purpose:

Hypotheses: 1) Airway pH regulation is abnormal in severe asthma; 2) In severe asthma, there is formation of cytotoxic nitrogen oxides and loss of beneficial nitrogen oxides in the airways


Study summary:

Specific Aim 1:Test hypothesis that airway pH regulation is abnormal in severe asthma. 1a) Determine the effects of systemic corticosteroids on breath pH in children with severe and mild to moderate asthma. 1b) Examine whether breath condensate pH and other biomarkers of oxidant stress can predict clinical outcomes in children with severe and mild to moderate asthma. 1c) Identify whether increased Th1/Th2 cytokine ratio, and abnormalities in airway glutaminase, G-SNO-reductase, VATPase, and carbonic anhydrase are associated with airway pH disturbance in children with severe asthma. 1d) Test whether rhinovirus infections, which reduce airway pH, persist longer or are more frequent in children with severe asthma than in children with mild to moderate asthma. 1e) Examine the relationship between gastroesophageal reflux and proximal airway pH in children with severe asthma and mild to moderate asthma.


Criteria:

Inclusion Criteria: - At least 6 years old - Asthma diagnosis by physician - Current treatment with an inhaled corticosteroid medication


NCT ID:

NCT00590005


Primary Contact:

N/A


Backup Contact:

N/A


Location Contact:

Atlanta, Georgia 30322
United States

Eric Hunter, BS
Phone: 404-727-3691
Email: eric_hunter@oz.ped.emory.edu

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 23, 2018

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