Muncie, Indiana 47303


Purpose:

To test the hypothesis that localized functional reentry maintains Afib in humans, ibutilide will be administered intravenously in patients undergoing an Afib ablation. The hypothesis of this study is that ibutilide will decrease the high frequency signals observed in Afib suggesting the presence of micro reentrant circuits as the basic mechanism of Afib, especially for the paroxysmal Afib group. The potential difference in response to the ibutilide in patients with paroxysmal versus persistent Afib may show the difference in the underlying mechanism of Afib between these two groups.


Criteria:

Inclusion Criteria: - patients to be scheduled for atrial fibrillation radio frequency ablation - paroxysmal, permanent symptomatic atrial fibrillation refractory to conventional treatment - symptomatic atrial fibrillation that do not want or desire to take medication or undergo cardioversion - patients on antiarrhythmics that can be discontinued 5 half lifes prior to the procedure except for Amiodarone Exclusion Criteria: - patients with recent major hemorrhage (within 6 months) - patients with a coagulopathy - patients who are pregnant or breast feeding - patients with acute congestive heart failure - patients with hypokalemia or hyperkalemia - patients with a prolonged QTc > 440mms - patients with polymorphic ventricular tachycardia secondary to antiarrhythmic class III and class I - patients with left ventricular dysfunction < 40% - patients with a history of recent MI (< 1 month) - patients with a history of an angioplasty of < 1 month - patients with a history of coronary artery bypass grafting surgery of < 3 months. - patients with a history of chronic renal failure or a creatinine clearance of < 30ml/m - patients with a history of stroke of < 6 months


NCT ID:

NCT00589992


Primary Contact:

Principal Investigator
Antonio Navarrete, MD
Staff Physician, Ball Memorial Hospital

Antonio Navarrete, MD
Phone: 765-281-2000
Email: annavarr@mac.com


Backup Contact:

Email: skadair@medicalconsultantspc.com
Sherry Adair, RN
Phone: 765-254-4761


Location Contact:

Muncie, Indiana 47303
United States

Sherry Adair, RN
Phone: 765-254-4761
Email: skadair@medicalconsultantspc.com

Site Status: Recruiting


Data Source: ClinicalTrials.gov

Date Processed: January 20, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.


Click to view Full Listing

If you would like to be contacted by the clinical trial representative please fill out the form below.