Expired Study
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Rochester, Minnesota 55905


Purpose:

GLP-1 is an important incretin hormone which acts as a powerful insulin secretagogue. Defects in GLP-1 synthesis and secretion are thought to be part of the pathogenesis of type 2 diabetes. Furthermore GLP-1 based therapy is an important part of the therapeutic armamentarium for the treatment of type 2 diabetes. The GLP-1 receptor is the principal site of action of GLP-1 and GLP-1 receptor agonists like exenatide and liraglutide. The gene coding for this receptor, GLP1R, is highly polymorphic and contains numerous non-synonymous SNPs (nsSNPs) which could potentially alter response to endogenous or exogenous GLP-1 or GLP-1R agonists. Indeed there is some in vitro data to support this concept. We propose to utilize a hyperglycemic clamp to test the insulin secretory response to infused GLP-1 in healthy volunteers to determine the effect of genetic variation in GLP1R on response to GLP-1


Criteria:

Inclusion Criteria: - Aged 18-40 - fasting glucose concentration of less than 95 mg/dl. Exclusion Criteria: - Individuals with a BMI < 19 or > 40 kg/m2 - active systemic illness - medication that can alter gastric emptying, insulin secretion & action - history of abdominal surgery (other than appendectomy or tubal ligation).


NCT ID:

NCT00588380


Primary Contact:

Principal Investigator
Adrian Vella, MD
Mayo Clinic


Backup Contact:

N/A


Location Contact:

Rochester, Minnesota 55905
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

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