The purpose of this study is to find out whether a new device can help obtain more accurate
CT and PET scans of the lungs and chest tumors and the liver and liver tumors to help in
delivering radiation therapy. When we breathe, the amount of air in the lung changes. Lung
tumors may also move during breathing. Liver tumors may also move with breathing; as the
lungs inflate, the liver can be pushed down. A CT scan (a special type of X-ray) is
routinely obtained as part of planning for lung or liver radiation therapy. Since patients
breathe during this CT scan and their lung or liver tumors move, these CT scans can
sometimes be inaccurate. We are now testing a device to only obtain the CT and an additional
PET scan while patients are breathing in or out. This will hopefully allow us to deliver
radiation with more accuracy.
The objectives are to measure the amount of tumor motion with respiration, measure changes
in tumor definition with breathing synchronized PET compared to standard free breathing PET,
and to determine the fraction of patients whose radiation treatment plans would be modified
based on this information. Eligible patients are those receiving radiation treatment for
thoracic or liver tumors.
- Age ≥ 18 years old
- Ability to sign informed consent form indicating investigative nature of this study,
in keeping with the policies of the hospital.
- Patients must have thoracic disease visible on a Chest CT scan, or liver disease
visible on a abdominal CT scan.
- Pregnant women are ineligible. A pregnancy test will be performed on each fertile
premenopausal female prior to entry into the study.
- Patients with thoracic or liver disease that is not visible on CT scan
- Patients who are unable to follow directions either due to language difficulties or
- Patients who are too ill to hold their breath.