The purpose of this study is to see how people's diets, other aspects of their lifestyles,
and their individual genetic makeup affect their chances of getting endometrial cancer
(cancer of the uterus).
This survey will enroll several hundred women who have or have had endometrial cancer and
several hundred who do not. We will compare these two groups of women to see what factors may
lead to endometrial cancer.
We will conduct a population-based case-control study in six counties of New Jersey. Cases
will be women with newly-diagnosed endometrial or ovarian cancer. Controls will be matched by
5-year age groups and selected by random digit dialing (for those under 65), from Centers for
Medicare and Medicaid Services (CMS) files (for those 65 and over), or from neighborhood
sampling. Controls will not have had a hysterectomy.
There will be 400 cases with endometrioid tumors, 60 with serous tumors or clear cell tumors,
300 with ovarian cancer, and 400 controls. In addition, there will be a small group of black
women included from MSKCC.
We will interview participants about known and potential risk factors for endometrial and
ovarian cancer and obtain information on diet. We will obtain DNA for genetic analysis from
buccal specimens collected using a mouthwash rinse method. We will use logistic regression to
determine odds ratios for disease with various exposures. For endometrial cancer, we will
examine the association of risk with genotypes in strata defined by body mass index and
dietary fat consumption.
- Diagnosed with epithelial endometrial or ovarian cancer within the year before being
- Aged 21 and over
- Residents of Essex, Union, Morris, Middlesex, Bergen, or Hudson counties, NJ
- Black women with and without endometrial cancer who are seeing gynecologists at MSKCC
- Unable to sign informed consent
- Consent withheld by physician (cases)
- Hysterectomy (controls)
- Do not speak English or Spanish