This was a prospective, randomized, double blinded study in which patients undergoing a
cardiopulmonary bypass (CPB) with aortic cross clamping were randomly assigned to receive
amiodarone, lidocaine, or saline placebo prior to removal of the aortic cross clamp. (CPB
is a technique that temporarily takes over the function of the heart and lungs during
surgery, maintaining the circulation of blood and the oxygen content of the body.)
Specifically, we will test the hypothesis that amiodarone is superior to both lidocaine and
placebo in the prevention of a severely abnormal heart rhythm when the blood flow is
restored to the heart after the aortic cross clamp is removed.
This was a prospective, randomized, double blinded study in which patients undergoing
cardiopulmonary bypass with aortic cross clamping were randomly assigned to receive
amiodarone, lidocaine, or saline placebo prior to removal of the aortic cross clamp.
Specifically, we will test the hypothesis that amiodarone administration decreases the
incidence of ventricular fibrillation, the number of defibrillation attempts and the total
energy and current required for defibrillation should ventricular fibrillation occur.
- Patients undergoing cardiac surgery that was expected to include cross-clamping of
- Women wishing to become pregnant within 6 months of surgery
- Allergy to amiodarone
- History of organ dysfunction due to previous amiodarone use
- Patients who require more than mild systemic hypothermia (<32 degrees C) during
- Patients who require more than one bypass run or more than one period of aortic