Expired Study
This study is not currently recruiting Study Participants on ClinicalConnection.com. If you would like to find active studies please search for clinical trials.

New York, New York 10065


We postulate that multiple apoptototic events are indusce through testosterone depletion and repletion with taxotere given in conjunction with androgen withdrawal.


Inclusion Criteria: - Diagnosis of prostate adenocarcinoma histologically confirmed at MSKCC or SKCCC. - Patient must have a serum testosterone > 180 ng/dl. - Karnofsky performance status (KPS)>_70%. - Patients must have adequate organ function as defined by the following - laboratory criteria: - WBC >_ 3500/mm3 - ANC >_1500/mm3 - Platelet count >100,000/mm3 - Hemoglobin >8.0g/dL - Creatinine <1.6mg/dl - Total Bilirubin WNL (unless due to Gilbert's disease and other LFTs are WNL) - SGOT and SGPT If alkaline phosphatase is _< 2.5 x ULN, any elevations in - AST/ALT; OR if AST/ALT is _<1.5 x ULN, any elevation in alkaline phos - Prior hormonal therapy is allowed as: 1. Neoadjuvant treatment prior to radiation therapy or radical pmstatectomy, provided that the total duration of therapy does not exceed 6 months (Proscar is not considered a hormone therapy). 2. One cycle of intermittent therapy up to a maximum exposure of 6 months (Proscar is not considered a hormone therapy). - Patients must be at least 18 years of age. - Patients must have signed an informed consent document stating that they understand the investigational nature of the proposed treatment Exclusion Criteria: - Clinically significant cardiac disease (New York Heart Association Class III/IV), or severe debilitating pulmonary disease. - Uncontrolled serious active infection. - Anticipated survival of less than 3 months. - Active CNS or epiduraltumor - Inability or unwillingness to comply with the treatment protocol, follow-up, or research tests - Peripheral neuropathy >_ grade 3. - Patients with a history of severe hypersensitivity reaction to drugs formulated with polysorbate 80. - Men of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 6 months after completion of the treatment. - Prior chemotherapy - Concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital, St. Johns's Wort (hypericum perforatum) and ketoconazole is prohibited.



Primary Contact:

Principal Investigator
Dana Rathkopf, MD, PhD
Memorial Sloan-Kettering Cancer Center

Backup Contact:


Location Contact:

New York, New York 10065
United States

There is no listed contact information for this specific location.

Site Status: N/A

Data Source: ClinicalTrials.gov

Date Processed: March 16, 2018

Modifications to this listing: Only selected fields are shown, please use the link below to view all information about this clinical trial.

Click to view Full Listing

This study is not currently recruiting Study Participants on ClinicalConnection.com. The form below is not enabled.