The purpose of this study is to see if dynamic contrast enhanced (DCE) MRI imaging makes it
possible to distinguish benign conditions of the breast from malignant tumors and provide
better information than can be obtained with regular MRI. DCE MRI uses a new way of
collecting and analyzing the images or pictures which provides doctors extra information not
available with standard imaging methods. This includes information about the blood vessels
of different breast diseases. Pictures produced this way look just like the regular MRI
pictures. The DCE MRI adds another imaging sequence (another scan) to the MRI examination
ordered by your physician to evaluate your breast lesion, thus increasing the exam time
(extra 10 min). The information gained from doing the new test, the DCE MRI, will not be
used in your treatment and will not affect the type of care you receive for your breast
Our aim is to perform dynamic contrast enhanced (DCE) MRI on 150 patients during their
routine breast MRI examination at MSKCC. This will add extra 10 min scanning time to the
routine examination. High resolution (submillimeter) parametric maps of pathophysiologic
quantities, such as tumor vessel permeability, tumor perfusion, extracellular extravascular
volume fraction, will be generated from the DCE MRI data. These results will be correlated
with pathology to determine new pharmacokinetic threshold so that the negative predictive
value for benign lesions is close to 100%. The improvement in diagnostic specificity may
help to reduce unnecessary biopsies in the future.
· scheduled for breast MRI interventional procedure for a known breast lesion.
- patients who would be normally excluded from undergoing an MRI examination patients
with a pacemaker, aneurysm clip or any other condition that would warrant avoidance
of a strong magnetic field.
- patients who are unable to cooperate for an MRI, and/or have known reaction to
gadolinium contrast agent.