Expired Study
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Indianapolis, Indiana 46202


Purpose:

We will directly test the hypothesis that an initial strategy of lisinopril-based therapy will be more effective than atenolol-based therapy in causing regression of LVH over one year in patients with hemodialysis hypertension despite similar degree of BP reduction.


Study summary:

This is a parallel group, active control, single-center, open-label, randomized controlled trial comparing the safety and efficacy of initial therapy with an ACE inhibitor (lisinopril) vs. beta-blocker therapy (atenolol) each administered three times weekly after dialysis.


Criteria:

Inclusion Criteria: 1. Patients on chronic hemodialysis for > 3 mos. 2. Compliance with hemodialysis treatments as defined by less than one missed dialysis per month 3. Hypertension as diagnosed by ABPM >135/75 mm Hg after participation in the UF Trial, or those on no antihypertensive medications but unwilling to do UF Trial. 4. Presence of LVH on echocardiogram defined as LVMi >104 g/m2 in women and >116 g/m2 in men. 5. Willingness to give informed consent. Exclusion criteria: 1. Vascular event (stroke, myocardial infarction or limb ischemia requiring bypass) within previous six months 2. Noncompliance with hemodialysis treatments 3. Known drug abuse 4. COPD requiring home oxygen 5. Congestive Heart Failure Class III or IV. 6. Body mass index > 40 kg/m2. 7. Known contraindication to atenolol (severe heart failure, bradycardia, bronchial asthma, intolerance or allergy) or lisinopril (cough, pregnancy, intolerance or allergy)


NCT ID:

NCT00582114


Primary Contact:

Principal Investigator
Rajiv Agarwal, MD
Indiana University


Backup Contact:

N/A


Location Contact:

Indianapolis, Indiana 46202
United States



There is no listed contact information for this specific location.

Site Status: N/A


Data Source: ClinicalTrials.gov

Date Processed: January 18, 2018

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