We will directly test the hypothesis that an initial strategy of lisinopril-based therapy
will be more effective than atenolol-based therapy in causing regression of LVH over one
year in patients with hemodialysis hypertension despite similar degree of BP reduction.
This is a parallel group, active control, single-center, open-label, randomized controlled
trial comparing the safety and efficacy of initial therapy with an ACE inhibitor
(lisinopril) vs. beta-blocker therapy (atenolol) each administered three times weekly after
1. Patients on chronic hemodialysis for > 3 mos.
2. Compliance with hemodialysis treatments as defined by less than one missed dialysis
3. Hypertension as diagnosed by ABPM >135/75 mm Hg after participation in the UF Trial,
or those on no antihypertensive medications but unwilling to do UF Trial.
4. Presence of LVH on echocardiogram defined as LVMi >104 g/m2 in women and >116 g/m2 in
5. Willingness to give informed consent.
1. Vascular event (stroke, myocardial infarction or limb ischemia requiring bypass)
within previous six months
2. Noncompliance with hemodialysis treatments
3. Known drug abuse
4. COPD requiring home oxygen
5. Congestive Heart Failure Class III or IV.
6. Body mass index > 40 kg/m2.
7. Known contraindication to atenolol (severe heart failure, bradycardia, bronchial
asthma, intolerance or allergy) or lisinopril (cough, pregnancy, intolerance or