Cryogen Spray Cooling spurt is applied to the skin surface immediately before laser
exposure. As liquid cryogen rapidly evaporates, the superficial skin temperature is reduced
as a result of supplying the latent heat of vaporization. Tetrafluoroethane, an
environmentally compatible, non-toxic, non-flammable freon substitute, has been demonstrated
in multiple studies to be a safe and effective cooling agent and is the only cryogenic
compound currently approved for dermatologic use by the Food and Drug Administration.
The researcher can use laser treatment in combination with Cryogen Spray Cooling. The
specific aim of this study is to characterize the clinical cutaneous effects of varying
spurt durations and spurt delivery patterns that spurt durations of 100 ms or less will
result in a very low incidence (less than 2%) of clinical skin effects (redness, blistering,
local skin allergic reaction or skin discoloration) in any skin type.
Researchers can use Cryogen Spray Cooling to protect the skin epidermis during laser therapy
to decrease treatment pain, allow safe treatment of darker skin types, and safe use of high
laser fluences. Cryogen Spray Cooling with Tetrafluoroethane has been incorporated into many
Food and Drug Administration approved, commercially available laser devices currently used
for treatment of vascular lesions, hair removal and non-ablative skin rejuvenation.
- Adult 18 years and older
- Age <18
- History of cold sensitivity
- Inflammatory rash on the test site