The purpose of this study will be to assess the attentional ability of patients with mild to
moderate traumatic brain injury (TBI) using the functional Magnetic Resonance Imaging (fMRI)
technique. Methodology for specific aim 1: sagittal pilot scan, 3-D anatomical MRI, Whole
brain echo-planar imaging (EPI), and functional MRI techniques with traumatic brain injured
subjects doing a Continuous Performance Test (CPT) attention task and compare the pattern of
activation with those of normal controls to see if there is a failure to activate frontal
lobes in the traumatic brain injured subjects.
- Mild to moderate brain injury patients referred to the UCI Brain Imaging Center.
- Mild brain injury patients will be defined as having a Glascow Coma Scale (GCS)
scale of 13-15.
- Moderate brain injury brain injury patients will be defined as having a Glascow
Coma Scale (GCS) scale of 9-12 .
- Normal healthy control subjects (20)
- Pre-accident neuropathology, psychopathology, or secondary neuropathological
complications, or chemical abuse
- Patients who required intracranial surgical intervention
- Children, pregnant women, or institutionalized individuals unable to freely give
- Patients with implanted surgical clips (hemostatic clips) or other ferromagnetic
- Patients engaged in occupations or activities which may cause accidental lodging of
ferromagnetic materials, or who may have imbedded metal fragments from military
- Patients with permanent (tattoo) eye-liner or with facial make-up (severe eye
irritation has been reported)
- Patients with metallic implants, because they may cause artifacts in diagnostic
images due to magnetic field distortion
- Patients with implanted prosthetic heart valves
- Patients with pacemakers, neuro-stimulation devices
- Subjects who have severe claustrophobia.
Joseph C Wu, M.D.
University of California, Irvine
Joseph C Wu, M.D.